منابع مشابه
Mechanism of interaction of CC-1065 (NSC 298223) with DNA.
CC-1065 (NSC 298223), a potent new antitumor antibiotic produced by Streptomyces zelensis, interacts strongly with double-stranded DNA and appears to exert its cytotoxic effects through disruption of DNA synthesis. We undertook this study to elucidate the sites and mechanisms of CC-1065 interaction with DNA. The binding of CC-1065 to synthetic and native DNA was examined by differential circula...
متن کاملGilvusmycin, a new antitumor antibiotic related to CC-1065.
A new antitumor antibiotic gilvusmycin was isolated from the culture broth of Streptomyces sp. QM16. The structure of gilvusmycin was related to CC-1065 and determined by NMR spectral analysis. Gilvusmycin exhibited antitumor activity against murine leukemia P388 in vivo.
متن کاملSynthesis and cytotoxicity of a biotinylated CC-1065 analogue
BACKGROUND: The use of pretargeting technology for cancer imaging and treatment has made significant progress in the last few years. This approach takes advantage of the fact that biotin binds strongly to proteins avidin and streptavidin. Thus, a non-toxic tumor cell specific antibody is conjugated with avidin/streptavidin, and is administered to patients. After the antibody binds to tumor cell...
متن کاملChemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.
CC-1065, the duocarmycins and yatakemycin are members of a family of ultrapotent antitumour antibiotics that have been the subject of extensive investigations due to their mode of action and potential in the design of new anticancer therapeutics. The natural products and their analogues exert their effects through a sequence selective alkylation of duplex DNA in the minor groove at the N3 of ad...
متن کاملThe Structure of CC-1065, a Potent Antitumor Agent, and Its Binding to DNA
The crystal and molecular structure of a potent antitumor agent, CC1065 (C37H33N708), has been determined, and circular dichroism studies have demonstrated a strong interaction between CC-1065 and DNA. The triclinic unit cell, space group P1, of dimensions a = 11.063 (3) A, b = 13.311 (2) A, c = 13.405 (2) A, a = 85.18 (1)O, @ = 99.52 (l)', and y = 103.36 (2)O, contains two CC-1065 molecules an...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1985
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.38.746